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La hiptesis pre-ensayo era sinergia mecanstica
Nauck MA, Heimesaat MM, Orskov C, Holst JJ, Ebert R, Creutzfeldt W (1993) Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus
Between early 2022 and mid-2024, more than 6 million patients were identified with a type 2 diabetes diagnosis
Efectos secundarios GI frecuentes Nuseas Semaglutida 2,4 mg ~44 % Tirzepatida 15 mg ~31 % Retatrutida 12 mg ~45 % Diarrea Semaglutida 2,4 mg ~30 % Tirzepatida 15 mg ~23 % Retatrutida 12 mg ~39 % Vmitos Semaglutida 2,4 mg ~24 % Tirzepatida 15 mg ~12 % Retatrutida 12 mg ~20 % Estreimiento Semaglutida 2,4 mg ~24 % Tirzepatida 15 mg ~11 % Retatrutida 12 mg ~16 % Interrupcin por EA Semaglutida 2,4 mg ~7 % Tirzepatida 15 mg ~6 % Retatrutida 12 mg ~6 % Algunas observaciones de los datos publicados: Semaglutida tiene un perfil GI bien caracterizado a partir de un uso clnico extenso
